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<div class=3DSection1>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'>A Case of Malignant Maladaptation:<o:p></o:p></s=
pan></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'>Human Occupation of Global Ecosystems<o:p></o:p>=
</span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'>Warren M. Hern, M.D., M.P.H., Ph.D.<o:p></o:p></=
span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'>Associate professor Adjunct<o:p></o:p></span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'>Department of Anthropology<o:p></o:p></span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'>Research Associate<o:p></o:p></span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'>Environment &amp; Behavior Program<o:p></o:p></s=
pan></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><st1:place =
w:st=3D"on"><st1:PlaceType
 w:st=3D"on"><span style=3D'font-size:14.0pt'>Institute</span></st1:PlaceTy=
pe><span
 style=3D'font-size:14.0pt'> of <st1:PlaceName w:st=3D"on">Behavioral Scien=
ce</st1:PlaceName></span></st1:place><span
style=3D'font-size:14.0pt'><o:p></o:p></span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><st1:place =
w:st=3D"on"><st1:PlaceType
 w:st=3D"on"><span style=3D'font-size:14.0pt'>University</span></st1:PlaceT=
ype><span
 style=3D'font-size:14.0pt'> of <st1:PlaceName w:st=3D"on">Colorado</st1:Pl=
aceName></span></st1:place><span
style=3D'font-size:14.0pt'><o:p></o:p></span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><st1:place =
w:st=3D"on"><st1:City
 w:st=3D"on"><span style=3D'font-size:14.0pt'>Boulder</span></st1:City><span
 style=3D'font-size:14.0pt'>, <st1:State w:st=3D"on">Colorado</st1:State> <=
st1:PostalCode
 w:st=3D"on">80309-0233</st1:PostalCode></span></st1:place><span
style=3D'font-size:14.0pt'><o:p></o:p></span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'>Presented
at the Symposium: Why Adaptation Becomes Maladaptive: The Dynamics of
Population Growth and Resources.<span style=3D'mso-spacerun:yes'>&nbsp;
</span>161<sup>st</sup> Annual Meeting of the American Association for the
Advancement of Science, February 21, 1994<span
style=3D'mso-spacerun:yes'>&nbsp;&nbsp;&nbsp; </span><st1:place w:st=3D"on"=
><st1:City
 w:st=3D"on">San Francisco</st1:City>, <st1:State w:st=3D"on">California</s=
t1:State></st1:place><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span class=3DGramE><span
style=3D'font-size:14.0pt'>Role<span style=3D'mso-spacerun:yes'>&nbsp; </sp=
an>of</span></span><span
style=3D'font-size:14.0pt'> human culture in malignant change:<o:p></o:p></=
span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'>Provides adaptations to overcome
biological &amp; ecological limitations of human organism<o:p></o:p></span>=
</b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span class=3DGramE><b
style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:14.0pt'>Adap=
tations </span></b><span
style=3D'font-size:14.0pt'><span style=3D'mso-spacerun:yes'>&nbsp;</span>(<=
/span></span><span
style=3D'font-size:14.0pt'>high survival value)<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span>Language<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span>Agriculture<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span>Weapons<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span>Shelter<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span>Medical
care<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span>Fertility
limitation<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span>Elimination
of predators (of humans)<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span>Exploitation
of organic and inorganic environment<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span>Dominance
of ecosystems<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'>Maladaptations</span></b><span
style=3D'font-size:14.0pt'><span style=3D'mso-spacerun:yes'>&nbsp; </span>(=
zero
survival value)<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span>Destruction
of non-human environment (deforestation, pollution, etc)<o:p></o:p></span><=
/p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span>Simplification
of ecosystems (agriculture, urbanization, grazing)<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span>Loss
of biodiversity (flora and fauna); increased extinction rates<o:p></o:p></s=
pan></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span>Unrestrained
global population growth<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span>Dominance
of all ecosystems<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'>Characteristics of malignant proce=
ss<o:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'margin-left:.5in;text-align:justify;text-inde=
nt:-.25in;
mso-list:l0 level1 lfo2;tab-stops:list .5in'><![if !supportLists]><span
style=3D'font-size:14.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>&middot;<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;
</span></span></span><![endif]><span style=3D'font-size:14.0pt'>Rapid,
uncontrolled growth<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-left:.5in;text-align:justify;text-inde=
nt:-.25in;
mso-list:l0 level1 lfo2;tab-stops:list .5in'><![if !supportLists]><span
style=3D'font-size:14.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>&middot;<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;
</span></span></span><![endif]><span style=3D'font-size:14.0pt'>Invasion &a=
mp; destruction
of adjacent normal tissues<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-left:.5in;text-align:justify;text-inde=
nt:-.25in;
mso-list:l0 level1 lfo2;tab-stops:list .5in'><![if !supportLists]><span
style=3D'font-size:14.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>&middot;<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;
</span></span></span><![endif]><span style=3D'font-size:14.0pt'>Metastasis
(distant colonization)<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-left:.5in;text-align:justify;text-inde=
nt:-.25in;
mso-list:l0 level1 lfo2;tab-stops:list .5in'><![if !supportLists]><span
style=3D'font-size:14.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>&middot;<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;
</span></span></span><![endif]><span style=3D'font-size:14.0pt'>De-differen=
tiation
(loss of specialized appearance, morphology, and function at individual cell
level)<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-left:.25in;text-align:justify'><span
style=3D'font-size:14.0pt'><span style=3D'mso-spacerun:yes'>&nbsp;&nbsp; </=
span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-left:.25in;text-align:justify'><span
style=3D'font-size:14.0pt'><span
style=3D'mso-spacerun:yes'>&nbsp;&nbsp;&nbsp;&nbsp; </span>(At least two
characteristics are necessary to establish the diagnosis of malignancy)<o:p=
></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-left:.25in;text-align:justify'><span
style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'>Comparisons of human population wi=
th
malignant processes:<o:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'margin-left:.5in;text-align:justify;text-inde=
nt:-.25in;
mso-list:l0 level1 lfo2;tab-stops:list .5in'><![if !supportLists]><span
style=3D'font-size:14.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>&middot;<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;
</span></span></span><![endif]><span style=3D'font-size:14.0pt'>Rapid,
uncontrolled growth of global population<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-left:.5in;text-align:justify;text-inde=
nt:-.25in;
mso-list:l0 level1 lfo2;tab-stops:list .5in'><![if !supportLists]><span
style=3D'font-size:14.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>&middot;<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;
</span></span></span><![endif]><span style=3D'font-size:14.0pt'>Invasion and
destruction of all planetary ecosystems<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-left:.5in;text-align:justify;text-inde=
nt:-.25in;
mso-list:l0 level1 lfo2;tab-stops:list .5in'><![if !supportLists]><span
style=3D'font-size:14.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>&middot;<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;
</span></span></span><![endif]><span style=3D'font-size:14.0pt'>Colonizatio=
n and
urbanization; settlement fission<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-left:.5in;text-align:justify;text-inde=
nt:-.25in;
mso-list:l0 level1 lfo2;tab-stops:list .5in'><![if !supportLists]><span
style=3D'font-size:14.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>&middot;<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;
</span></span></span><![endif]><span style=3D'font-size:14.0pt'>De-differen=
tiated
through biology and culture<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'>De-differentiation in human proces=
s<o:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><span
style=3D'mso-spacerun:yes'>&nbsp;&nbsp; </span>&#8220;</span></b><span
style=3D'font-size:14.0pt'>De-differentiation&#8221; of humans biologically=
 &amp;
through culture means:<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-left:.5in;text-align:justify;text-inde=
nt:-.25in;
mso-list:l0 level1 lfo2;tab-stops:list .5in'><![if !supportLists]><span
style=3D'font-size:14.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>&middot;<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;
</span></span></span><![endif]><span style=3D'font-size:14.0pt'>Biologicall=
y,
humans are unspecialized, and they are virtually identical throughout the
planet<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-left:.5in;text-align:justify;text-inde=
nt:-.25in;
mso-list:l0 level1 lfo2;tab-stops:list .5in'><![if !supportLists]><span
style=3D'font-size:14.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>&middot;<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;
</span></span></span><![endif]><span style=3D'font-size:14.0pt'>Culture per=
mits
humans to be <b style=3D'mso-bidi-font-weight:normal'>undifferentiated</b>
exploiters of all ecosystems<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin-left:.5in;text-align:justify;text-inde=
nt:-.25in;
mso-list:l0 level1 lfo2;tab-stops:list .5in'><![if !supportLists]><span
style=3D'font-size:14.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>&middot;<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;
</span></span></span><![endif]><span style=3D'font-size:14.0pt'>At aggregate
level, human communities are increasingly <b style=3D'mso-bidi-font-weight:=
normal'>undifferentiated</b>
in morphology, structure, function, appearance, invasiveness of adjacent ar=
eas<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'>A <u>malignant
neoplasm</u> is &#8220;<b style=3D'mso-bidi-font-weight:normal'>&#8230;an
uncontrolled new growth of tissue&#8230;which has the power of growth and
multiplication relatively free from the usual restraints&#8230;&#8221;<span
style=3D'mso-spacerun:yes'>&nbsp; </span></b><span
style=3D'mso-spacerun:yes'>&nbsp;</span><st1:place w:st=3D"on"><st1:City w:=
st=3D"on">Anderson</st1:City></st1:place>,
<u>Pathology</u>, 1960, p. 443<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'>&#8220;&#8230;once a cell becomes
malignant it does not revert to normal.&#8221;</span></b><span
style=3D'font-size:14.0pt'><span style=3D'mso-spacerun:yes'>&nbsp; </span><=
st1:place
w:st=3D"on"><st1:City w:st=3D"on">Anderson</st1:City></st1:place>, <u>Patho=
logy</u>,
1960, p. 443<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'>How Many Times Has The Human Popul=
ation
Doubled?<o:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span>5.6
x <span class=3DGramE>10<sup>9</sup><span style=3D'mso-spacerun:yes'>&nbsp;
</span>=3D</span><span style=3D'mso-spacerun:yes'>&nbsp; </span>2<sup>x</su=
p><span
style=3D'mso-spacerun:yes'>&nbsp; </span>where x is the number of doublings=
,<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-spacerun:yes'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;
</span><span class=3DGramE>x<span style=3D'mso-spacerun:yes'>&nbsp; </span>=
=3D</span><span
style=3D'mso-spacerun:yes'>&nbsp;&nbsp;&nbsp; </span><u>ln 5.6 x 10<sup>9</=
sup> </u><span
style=3D'mso-spacerun:yes'>&nbsp;&nbsp;&nbsp;</span>=3D<span
style=3D'mso-spacerun:yes'>&nbsp;&nbsp;&nbsp; </span><u>22.446</u><span
style=3D'mso-spacerun:yes'>&nbsp;&nbsp;&nbsp;&nbsp; </span>=3D<span
style=3D'mso-spacerun:yes'>&nbsp;&nbsp;&nbsp; </span>32.38<o:p></o:p></span=
></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-spacerun:yes'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nb=
sp;&nbsp;&nbsp;&nbsp;
</span><span class=3DGramE>ln</span> 2<span
style=3D'mso-spacerun:yes'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</span>0.693<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span><b
style=3D'mso-bidi-font-weight:normal'>The 32<sup>nd</sup> doubling was reac=
hed in
1976</b><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'>In
organismic cancer:<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><span style=3D'mso-tab-count:1'>&n=
bsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span>A
malignant tumor at 1 cm diameter (1 gm) contains<o:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><span style=3D'mso-tab-count:2'>&n=
bsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp=
;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span>10<sup>9</sup><span
style=3D'mso-spacerun:yes'>&nbsp; </span>(1 billion) cells<span
style=3D'mso-spacerun:yes'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</span>(30 doublings)<o:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><span style=3D'mso-tab-count:1'>&n=
bsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span>Death
of the host organism occurs at 37-40 doublings<o:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'>Current
human population doubling times and growth rates:<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span>1950
<span class=3DGramE>-<span style=3D'mso-spacerun:yes'>&nbsp; </span>2.5</sp=
an> billion;
1987 &#8211; 5 billion<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span><b
style=3D'mso-bidi-font-weight:normal'>Doubling time: 87 years; Mean growth =
rate:
1.87% / year<o:p></o:p></b></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><span style=3D'mso-tab-count:1'>&n=
bsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span></b><span
style=3D'font-size:14.0pt'>1956 &#8211; 2.8 billion<span class=3DGramE>;<sp=
an
style=3D'mso-spacerun:yes'>&nbsp; </span>1993</span> &#8211; 5.6 billion<o:=
p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:1'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp; </span><b
style=3D'mso-bidi-font-weight:normal'>Doubling time: 37 years; Mean growth =
rate:
1.87% per year<o:p></o:p></b></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'>At the current rate of growth (1.9=
% per
year), the human population will reach the following doublings in the years=
:<o:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><span style=3D'mso-tab-count:2'>&n=
bsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp=
;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span>37
doublings &#8211; 170 years<span style=3D'mso-spacerun:yes'>&nbsp;&nbsp; </=
span>(</span></b><span
style=3D'font-size:14.0pt'>c. 2165)<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:2'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span><b
style=3D'mso-bidi-font-weight:normal'>40 <span class=3DGramE>doublings<span
style=3D'mso-spacerun:yes'>&nbsp; </span>-</span><span
style=3D'mso-spacerun:yes'>&nbsp; </span>280 years<span
style=3D'mso-spacerun:yes'>&nbsp;&nbsp; </span></b>(c. 2275)<o:p></o:p></sp=
an></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'>Human Species as a Cancer on the P=
lanet:<o:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><span style=3D'mso-tab-count:2'>&n=
bsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp=
;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span></b><span
class=3DGramE><span style=3D'font-size:14.0pt'>Analogy?</span></span><span
style=3D'font-size:14.0pt'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:2'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span><span
class=3DGramE>Metaphor?</span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:2'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span><span
class=3DGramE>Hypothesis?</span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><span
style=3D'mso-tab-count:2'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&=
nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span><span
class=3DGramE>Diagnosis?</span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'>No one ever died from an analogy<o=
:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'>If
cancer is the diagnosis, what is the prognosis?<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><span style=3D'font-size:=
14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'>A malignant process continues unti=
l the
host organism has ceased to function (it dies)<o:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'>NOT<o:p></o:p></span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><b style=3D=
'mso-bidi-font-weight:
normal'><span style=3D'font-size:14.0pt'>Homo sapiens<o:p></o:p></span></b>=
</p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'>&#8220;Wise man&#8221;<o:p></o:p></span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'>BUT<o:p></o:p></span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><b style=3D=
'mso-bidi-font-weight:
normal'><span style=3D'font-size:14.0pt'>Homo ecophagus</span></b><span
style=3D'font-size:14.0pt'><o:p></o:p></span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'>&#8220;The man who devours the ecosystem&#8221;<=
o:p></o:p></span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dcenter style=3D'text-align:center'><span
style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'text-align:justify'><b style=3D'mso-bidi-font=
-weight:
normal'><span style=3D'font-size:14.0pt'><span style=3D'mso-tab-count:1'>&n=
bsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span>&#8220;It
is with the coming of man that a vast hole seems to open in nature, a vast
black whirlpool spinning faster and faster, consuming flesh, stones, soil,
minerals, sucking down the lightning, wrenching power from the atom, until =
the
ancient sounds of nature are drowned in the cacaphony of something which is=
 no
longer nature, something instead which is loose and knocking at the
world&#8217;s heart, something demonic and no longer planned &#8211; escape=
d,
as it may be &#8211;spewed out of nature, contending in a final giant&#8217=
;s
game against its master.&#8221;<o:p></o:p></span></b></p>

<p class=3DMsoNormal align=3Dright style=3D'text-align:right'><b style=3D'm=
so-bidi-font-weight:
normal'><span style=3D'font-size:14.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal align=3Dright style=3D'text-align:right'><span style=
=3D'font-size:
14.0pt'>Loren Eiseley, <span class=3DGramE><u>The</u></span><u> Firmament of
Time, 1960 <o:p></o:p></u></span></p>

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